Autoimmune polyendocrine failure
Polyglandular autoimmune syndrome, Smith-Carpenter syndrome
In autoimmune polyendocrine failure can now define the difference between two types:
Type 1: This form begins in childhood with an underactive parathyroid glands (hypoparathyroidism), and an infection by the fungus Candida albicans (candidiasis). Later in Addison's disease, a Hashimoto-Thyreoidits, diabetes mellitus type I and one ovarian gegebenenfalss add one.
Outside of the endocrine organ system can develop a vitiligo and pernicious anemia.
Type 2: This is the real Schmidt-Carpenter syndrome. The disease begins later and more preferably the female gender. Patients diagnosed with a rare hyperparathyroidism. Rather, the emphasis on the Addison's disease, Hashimoto's thyroiditis, type I diabetes mellitus and hypogonadism.
At extra endocrine diseases, in addition to the Vitiligo and pernicious anemia occasionally occur a sprue and a myasthenia gravis.
For this form of autoimmune polyendocrine failure an autosomal dominant inheritance is demonstrated.